William Hume may refer to:

• Bill Hume (footballer) (1937–2005), English-born soccer player who played for New Zealand and Australia
• Bill Hume (cartoonist) (1916–2009), American artist, art director, and newspaper man
• Billy Hume (1935–1990), Scottish footballer
• Willie Hume (1862–1941), cyclist, first ever winner on Dunlop pneumatic tyres
• William Hume (Cape politician) (1837–1916), politician of the Cape Colony
• William Errington Hume (1879–1960), English physician (knighted in 1952)
• William H. Hume, American architect in New York City
• William J. Hume, American heir, businessman and conservative philanthropist
• William Fraser Hume (1867–1949), British geologist