Oscar Rodriguez may refer to:

• Oscar Rodríguez Naranjo (1907–2006), Colombian painter
• Óscar Rodríguez Maradiaga (born 1942), Honduran prelate of the Catholic Church
• Oscar Samson Rodriguez (born 1945), Filipino lawyer and politician
• Óscar Rodríguez Cabrera (born 1964), Mexican politician
• Óscar Rodríguez (cyclist) (born 1995), Spanish cyclist
• Óscar Rodríguez (footballer, born 1980), Spanish footballer
• Óscar Rodríguez (footballer, born 1998), Spanish footballer
• Oscar Rodriguez (American football), American football coach
• Óscar Rodríguez (Paraguayan politician) (born 1981), mayor of Asunción in 2019–2025