Oscar Rodriguez may refer to:

• Oscar Rodríguez Naranjo (1907–2006), Colombian painter
• Óscar Rodríguez Maradiaga (born 1942), Honduran prelate of the Roman Catholic Church
• Oscar Samson Rodriguez (born 1945), mayor of San Fernando City, Pampanga, Philippines
• Óscar Rodríguez Cabrera (born 1964), Mexican politician
• Óscar Rodríguez (cyclist) (born 1995), Spanish cyclist
• Óscar Rodríguez (footballer, born 1980), Spanish footballer
• Óscar Rodríguez (footballer, born 1998), Spanish footballer
• Oscar Rodriguez (American football), American football coach
• Oscar Rodríguez (baseball), Cuban baseball player and manager
• Óscar Rodríguez (Paraguayan politician), Current Mayor (intendant) of the City of Asunción.