Blake Caldwell, MD PhD is a former American road bicycle racer. Notable results include placing second to Tyler Hamilton in the 2008 US Professional Road Race Championship in a photo finish losing to Hamilton by less than a tire's width. He also won stage 2 of the 2008 Tour of Utah, finishing 2nd in GC. His other professional win was stage 6 of the 2006 Tour of Utah. which was named 2006 Ride of the Year by cycling publication VeloNews.

As a junior cyclist, he won 11 Junior National Championships titles in road and track events and competed in the 2001 UCI Junior World Road Championships. In his first year as an amateur in 2003, he had Stagiaire rides in 2003 with US professional team Prime Alliance and UCI Professional Team Marco Polo. He joined Team 5280 Suburu (now known as EF_Education–EasyPost) in 2004. As a perennial member of the Slipstream cohort, he continued with team Slipstream into the UCI Pro Tour in 2009. He and several other Slipstream riders have found successful careers after retiring from professional cycling.

• Timmy Duggan (Real Estate)
• Steven Cozza (Real Estate)
• Will Frischkorn (Business Owner)
• Ian MacGregor (cyclist) (Skratch Labs CEO)
• Craig Lewis (cyclist) (Wine Distributor)