Rene Mandri (born 20 January 1984 in Jõgeva) is an Estonian former professional road bicycle racer, who competed as a professional between 2006 and 2012, with the Auber 93, Ag2r–La Mondiale and Endura Racing teams. He had a life-threatening crash in 2008 Giro d'Italia Stage 6. He has been working as cycling coach since 2014 and he is a recognized Sports Organisation Leader in Estonia with an IOC diploma. He created Cycling Tartu, a club to develop cycling in the Baltics. and was the U23 coach in Estonian Cyclists Union.

He now works as a directeur sportif for UCI ProTeam NSN Cycling Team. He previously worked as a team manager for UCI Continental team Voltas–Tartu 2024 by CCN. He expressed his regret that protesters against the Israeli–Palestinian conflict hindered his team's ability to participate in Giro dell'Emilia.