José Rodolfo Serpa Pérez (born 17 April 1979) is a Colombian road racing cyclist, who last rode for Colombian amateur squad Team Cartagena. He competed professionally between 2006 and 2015 and from 2018 to 2019, riding for UCI Professional Continental team Androni Giocattoli–Venezuela for seven years, spending three years with Lampre–Merida, and two years with GW–Shimano.

During his professional career, Serpa has taken almost twenty victories, with the majority of these coming at the Tour de Langkawi – where he won the overall race in 2009 and 2012, along with seven stage wins. He also won the time trial at the 2003 Pan American Games and the 2006 Central American and Caribbean Games, the road race at the 2006 Pan American Cycling Championships, and was the overall winner of the 2005–06 UCI America Tour.