Frantisek Sisr (born 17 March 1993) is a Czech former professional cyclist, who rode professionally between 2012 and 2020 for the Team Dukla Praha, Klein Constantia, CCC–Sprandi–Polkowice and Elkov–Kasper teams. He competed in the team pursuit event at the 2013 UCI Track Cycling World Championships, and won the Ronde van Drenthe in 2018. He now works as a directeur sportif for UCI Continental team Elkov–Kasper.