Van Den Driessche or Vandendriessche is a surname. Notable people with the surname include:

• Aurèle Vandendriessche (born 1932), Belgian long-distance runner
• Carlos Van den Driessche (1901–1972), Belgian ice hockey player and rower
• Femke Van den Driessche, Belgian cyclist
• Franky Vandendriessche (born 1971), Belgian footballer
• Gaston Vandendriessche (1924–2002), Belgian psychologist
• Kévin Vandendriessche (born 1989), French footballer
• Kurt Vandendriessche (born 1975), Belgian actor
• Lotte Vandendriessche (born 1997), Belgian volleyball player
• Pauline van den Driessche (born 1941), British-Canadian applied mathematician
• Pol Van Den Driessche, Belgian politician
• René Van Den Driessche (born 1928), Belgian fencer
• Tom Vandendriessche (born 1978), Belgian politician