Di Carlo is a surname with Germanic origins. Notable people with the surname include:

• Adelia Di Carlo (1883–1965), Argentine writer and chronicler
• Antonio Di Carlo (born 1962), Italian football player
• Domenico Di Carlo (born 1964), Italian football player and coach
• Elio Augusto Di Carlo (1918–1998), Italian ornithologist, historian and physician
• Francesco Di Carlo (1941–2020), Italian mafia informer
• Grégory Di Carlo (born 1993), French motorcycle racer
• Ray Di Carlo (early 21st c.), American producer and director