Josef Müller or Joseph Muller may refer to:

• Josef Müller (CSU politician) (1898–1979), German politician and member of the German Resistance
• Josef Müller (entomologist) (1880–1964), Croatian entomologist
• Josef Müller (footballer) (1893–1984), German footballer
• Josef Müller-Brockmann (1914–1996), graphic designer
• Josef Felix Müller (born 1955), Swiss sculptor, graphic artist and painter
• Joseph Muller (collector) (1883–1939), specialist in American music
• Joseph Müller (priest) (1894–1944), German Catholic priest and critic of the Nazi regime
• Joseph Muller (cyclist) (1895–1975), French cyclist
• Joseph E. Muller (1908–1945), American soldier and Medal of Honor recipient
• Joseph Maximilian Mueller (1894–1981), American prelate of the Roman Catholic Church
• Josef Müller (art collector) (1887–1977), Swiss art collector and curator